Laboratory Products
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Solution Phase Synthesis ScavengersStratoSpheres Scavengers are polystyrene functionalized resins designed for use in solution phase synthesis and purification. Scavengers are typically added at the end of a reaction where the specific functional group elicits a strong ionic interaction, or an irreversible covalent attachment with by-products and excess reagents.
> PL-AAEM Resin
A styrene/methacrylate copolymer matrix gives high load ketoester functionality, which is designed to selectively scavenge primary amines in the presence of secondary amines. PL-AAEM Resin is sold under license from Avecia. 'Scavenger Resin and Processes for the Use Thereof', Pears D A, WO 01/98378 A1, PCT Int Appl (2001). Application Notes (PDF format) > PL-BZA Resins
PL-BZA Resin is a polymer supported benzylamine, useful in the formation of traceless triazine linkers via reactions with aryl diazonium species and is prepared directly from our own copolymerized chloromethylstyrene resin. Application Notes (PDF format) > PL-CHO Resins
A high load benzaldehyde, particularly suited to scavenging primary amines or hydrazines and hydroxylamines. Application Notes (PDF format) > PL-Carboni Resins
PL-Carboni Resin is a diol resin in the protected acetonide form. The ability of the resin to form a stable six membered ring with boronic acid allows the resin to be used in two modes: firstly, to immobilize the boronic acid to allow modification of the aryl side chain or secondly, to act as a scavenger for residual boronic acid species. There are a limited number of commercially available phenylboronic acid derivatives and by immobilizing this type of compound onto the support it is possible to effect certain chemical transformations. The resin bound species can then be used directly in a Suzuki-Miyaura cross coupling reaction, for example, to create novel biaryl compounds. > PL-Carboni-Diol Resins
PL-Carboni-Diol Resin is the unprotected free diol form. The acetonide is converted to the free 1,3-diol by acidolysis. The ability of the resin to form a stable six membered ring with boronic acid allows the resin to be used in two modes: firstly, to immobilize the boronic acid to allow modification of the aryl side chain or secondly, to act as a scavenger for residual boronic acid species. There are a limited number of commercially available phenylboronic acid derivatives and by immobilizing this type of compound onto the support it is possible to effect certain chemical transformations. The resin bound species can then be used directly in a Suzuki-Miyaura cross coupling reaction, for example, to create novel biaryl compounds. Application Notes (PDF format) > PL-DEAM Resins
A polymer-supported diethanolamine for the immobilization of a variety of boronic acid compounds of the general formula R-B(OH)2, and the efficient trapping of boronic acid compounds from solution, a scavenging application. Application Notes (PDF format) > PL-DETA Resins
A high load amine resin for scavenging acids, acid chlorides and anhydrides. Application Notes (PDF format) > PL-EDA Resins
A high load amine resin for scavenging acids, acid chlorides and anhydrides. Application Notes (PDF format) > PL-MIA Resins
PL-MIA is designed to scavenge primary and secondary amines from solution. Application Notes (PDF format) > PL-MPH Resins
A high load tertiary amine base. Application Notes (PDF format) > PL-MPPZ Resins
A high load polymer-bound tertiary amine. Application Notes (PDF format) > PL-NCO Resins
Isocyanates are useful for scavenging a variety of nucleophiles. Unsuitable for use in aqueous solutions. Application Notes (PDF format) > PL-PIP Resins
Isocyanates are useful for scavenging a variety of nucleophiles. Unsuitable for use in aqueous solutions. Application Notes (PDF format) > PL-PPZ Resins
A high load polymer-bound amine. Application Notes (PDF format) > PL-SO2Cl Resins
PL-SO2Cl Resin is a scavenger resin that is particularly useful for the removal of basic compounds such as primary, secondary or tertiary amines. It can also be used where tosyl chloride would commonly be used as an activating agent. Alcohols, for example, can be immobilized onto PL-SO2Cl Resin and then released under nucleophilic displacement conditions. Application Notes (PDF format) > PL-SO2NHNH2Resins
A polymer supported sulfonylhydrazide for scavenging aldehydes and ketones. Application Notes (PDF format) > PL-SO3H Resins
PL-SO3H Resin is a scavenger resin that is particularly useful for the removal of basic compounds such as primary, secondary or tertiary amines. Application Notes (PDF format) > PL-TMT Resins
The solution phase reagent, trimercaptotriazine, has been used as a means of reducing levels of heavy metals, through precipitation, in a variety of applications. There is limited scope for using this reagent in organic solvents due to its solubility. PL-TMT MP-Resin is a polymer-bound version which exploits the efficacy of trimercaptotriazine towards a variety of heavy metal species, but can be readily filtered off afterwards regardless of solvent. By employing a specifically designed macroporous copolymer matrix, this reagent can be used in a variety of polar and non-polar solvents, including aqueous solutions. Application Notes (PDF format) > PL-Thiourea Resins PL-Thiourea MP-Resin is a macroporous product designed to provide strong interactions with a variety of heavy metal species. It may therefore be used to remove a number of organometallic catalysts from solution. Catalysts containing ruthenium (eg Grubbs and Grubbs-Hoveyda), rhodium (eg Wilkinsons) and numerous other metals (copper, tin, platinum, palladium, etc) can prove difficult to remove from pharmaceutical lead compounds. This may cause subsequent problems with cell-based assays unless levels can be reduced below 5ppm. By providing a macroporous resin containing a strong chelating functional site, residual metal content can be reduced significantly either in batchwise or flow through modes. Application Notes (PDF format) > PL-Urea Resins
PL-Urea MP-Resin is a macroporous product designed to provide strong interactions with a variety of heavy metal species. It may therefore be used to remove a number of organometallic catalysts from solution. Catalysts containing ruthenium (eg Grubbs and Grubbs-Hoveyda), rhodium (eg Wilkinsons) and numerous other metals (copper, tin, platinum, palladium, etc) can prove difficult to remove from pharmaceutical lead compounds. This may cause subsequent problems with cell-based assays unless levels can be reduced below 5ppm. By providing a macroporous resin containing a strong chelating functional site, residual metal content can be reduced significantly either in batchwise or flow through modes. |
